Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | FABP7 | O15540 | 1/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8773328 | 1.00 | TSHR (0.48) | TSHRGLAFABP7FABP5ALDH1A1 | |
| SCHEMBL6165123 | 1.00 | TSHR (0.48) | TSHRGLAFABP7FABP5ALDH1A1 | |
| SCHEMBL19234323 | 1.00 | TSHR (0.48) | TSHRGLAFABP7FABP5ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1784261 | 0.99 | TSHR (0.50) | TSHRGLAFABP7FABP5ALDH1A1 | |
| SCHEMBL7265457 | 0.85 | CA1 (0.48) | TSHRALDH1A1KMT2AFKBP1A | |
| SCHEMBL19233846 | 0.84 | GLA (0.47) | TSHRGLAFABP7FABP5ALDH1A1 | |
| SCHEMBL7436597 | 0.84 | TSHR (0.47) | TSHRGLAFABP7FABP5ALDH1A1 | |
| SCHEMBL29109592 | 0.84 | TSHR (0.53) | TSHRGLAFABP7FABP5ALDH1A1 | |
| SCHEMBL19233842 | 0.84 | TSHR (0.47) | TSHRGLAFABP7FABP5ALDH1A1 | |
| SCHEMBL11464612 | 0.82 | ALDH1A1 (0.50) | TSHRGLAFABP7FABP5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120289471-A1 | NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX | SIGNATURE R&D HOLDINGS, LLC (US) | 2012-11-15 | — | — | US | disclosed |
| US-8173840-B2 | Compounds with high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2012-05-08 | — | — | US | disclosed |
| WO-2007089745-A2 | NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX | SIGNATURE R & D HOLDINGS, LLC (US) | 2007-08-09 | — | — | WO | disclosed |
| US-20060241017-A1 | Novel compounds with high therapeutic index | SIGNATURE R&D HOLDINGS, LLC | 2006-10-26 | — | — | US | disclosed |
| EP-1472257-A1 | INHIBITORS OF ALPHA L BETA 2 INTEGRIN MEDIATED CELL ADHESION | TANABE SEIYAKU CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003066636-A1 | INHIBITORS OF ALPHA L BETA 2 INTEGRIN MEDIATED CELL ADHESION | TANABE SEIYAKU CO., LTD. (JP) | 2003-08-14 | — | — | WO | disclosed |
| EP-0544620-A1 | Macrocyclic lactams as inhibitors of atrial natriuretic factors (ANF)-degrading neutral endopeptidase (NEP) | CIBA-GEIGY AG (CH) | 1993-06-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289471-A1 | NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX | IL4I1, SLC7A1, GOT1 | TSHR 4639/4885GLA 3696/4885FABP7 260/4885 |
| US-20060241017-A1 | Novel compounds with high therapeutic index | IL4I1, SLC7A1, GOT1 | TSHR 4639/4885GLA 3696/4885FABP7 260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.