Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.64 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.57 |
| ▸ | RXRA | P19793 | 1/20 | 0.57 |
| ▸ | RXRB | P28702 | 1/20 | 0.57 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | MAOB | P27338 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPRB | P23467 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22275947 | 0.86 | APP (0.82) | APPNR4A2RXRARXRBNR4A1 | |
| SCHEMBL17248023 | 0.84 | MAPT (0.47) | APPRAB9ANPC1POLBLMNA | |
| SCHEMBL8773534 | 0.84 | MAOB (0.64) | MAOBPTPRCPTPN2PTPN1PTPRB | |
| SCHEMBL8773569 | 0.81 | MAOB (0.54) | APPRAB9ANPC1MAOBSMN1; SMN2 | |
| SCHEMBL1702727 | 0.81 | APP (0.74) | APPNR4A2RXRARXRBNR4A1 | |
| SCHEMBL13929695 | 0.80 | APP (0.72) | APPNR4A2RXRARXRBNR4A1 | |
| SCHEMBL13761551 | 0.80 | APP (0.72) | APPNR4A2RXRARXRBNR4A1 | |
| SCHEMBL13439792 | 0.80 | APP (0.72) | APPNR4A2RXRARXRBRAB9A | |
| SCHEMBL13439789 | 0.79 | APP (0.66) | APPNR4A2RXRARXRBNR4A1 | |
| SCHEMBL8773563 | 0.78 | RXRA (0.46) | APPNR4A2RXRARXRBNR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0577555-B1 | Derivatives of carboxylic acids | CIBA GEIGY AG (CH) | 1997-11-05 | — | — | EP | claimed |