Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.67 |
| ▸ | LTA4H | P09960 | 10/20 | 0.63 |
| ▸ | DRD2 | P14416 | 1/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.63 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.55 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.55 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5174028 | 0.99 | SLC6A3 (0.65) | SLC6A3LTA4HDRD2SLC6A4MCHR1 | |
| SCHEMBL7138812 | 0.89 | KCNH2 (0.76) | SLC6A3LTA4HDRD2SLC6A4MCHR1 | |
| SCHEMBL7140302 | 0.88 | LTA4H (0.73) | LTA4HMCHR1KCNH2PSMB1PSMB5 | |
| SCHEMBL1332021 | 0.84 | KCNH2 (0.64) | SLC6A3LTA4HDRD2SLC6A4KCNH2 | |
| SCHEMBL5864113 | 0.84 | LTA4H (0.73) | SLC6A3LTA4HMCHR1KCNH2HRH3 | |
| SCHEMBL5175894 | 0.83 | LTA4H (0.75) | LTA4HMCHR1MEN1LMNAHTT | |
| SCHEMBL18483417 | 0.83 | LTA4H (0.66) | SLC6A3LTA4HMCHR1KCNH2LMNA | |
| SCHEMBL5175647 | 0.83 | LTA4H (0.60) | LTA4HHTTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5175309 | 0.81 | LTA4H (0.85) | LTA4HHTTPSMB1PSMB5PSMB2 | |
| SCHEMBL13698801 | 0.81 | LTA4H (0.87) | LTA4HMCHR1MEN1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804427-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1996011192-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-04-18 | — | — | WO | disclosed |