Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ABAT | P80404 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774147 | 1.00 | SPHK1 (0.35) | SPHK1ADRB3ADRA1DSLC6A4ABAT | |
| SCHEMBL8774520 | 0.89 | SPHK1 (0.43) | SPHK1ACACB | |
| SCHEMBL8774507 | 0.89 | SPHK1 (0.43) | SPHK1ACACB | |
| SCHEMBL8774316 | 0.86 | SPHK1 (0.50) | SPHK1ACACB | |
| SCHEMBL8774311 | 0.86 | SPHK1 (0.50) | SPHK1ACACB | |
| SCHEMBL8774128 | 0.85 | SPHK1 (0.56) | SPHK1KDM4E | |
| SCHEMBL8774121 | 0.85 | SPHK1 (0.56) | SPHK1KDM4E | |
| SCHEMBL8774420 | 0.83 | DHODH (0.40) | DHODHKDM4EKDM1A | |
| SCHEMBL8774415 | 0.83 | DHODH (0.40) | DHODHKDM4EKDM1A | |
| SCHEMBL17156238 | 0.82 | KDM4E (0.40) | ADRB3ADRA1DSLC6A4ABATDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |