Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | NQO1 | P15559 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774415 | 1.00 | DHODH (0.40) | DHODHSYKNQO1KDM1AMRGPRX4 | |
| SCHEMBL8774070 | 0.89 | RAB9A (0.41) | MRGPRX4ALDH1A1RAB9AMAOAMAOB | |
| SCHEMBL8774616 | 0.89 | RAB9A (0.46) | KDM4ENPC1LMNARAB9A | |
| SCHEMBL8774077 | 0.89 | RAB9A (0.41) | MRGPRX4ALDH1A1RAB9AMAOAMAOB | |
| SCHEMBL8774625 | 0.89 | RAB9A (0.46) | KDM4ENPC1LMNARAB9A | |
| SCHEMBL8774998 | 0.87 | RAB9A (0.44) | KDM4ENPC1LMNARAB9A | |
| SCHEMBL8775002 | 0.87 | RAB9A (0.44) | KDM4ENPC1LMNARAB9A | |
| SCHEMBL8774073 | 0.83 | CHRNB2 (0.38) | DHODHSYKNQO1MRGPRX4KDM4E | |
| SCHEMBL8774966 | 0.83 | MRGPRX4 (0.35) | DHODHNQO1MRGPRX4KDM4EALDH1A1 | |
| SCHEMBL8774067 | 0.83 | CHRNB2 (0.38) | DHODHSYKNQO1MRGPRX4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |