Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 12/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774507 | 1.00 | SPHK1 (0.43) | SPHK1SPHK2ACACBNPC1TP53 | |
| SCHEMBL8774316 | 0.92 | SPHK1 (0.50) | SPHK1SPHK2ACACB | |
| SCHEMBL8774311 | 0.92 | SPHK1 (0.50) | SPHK1SPHK2ACACB | |
| SCHEMBL8774128 | 0.91 | SPHK1 (0.56) | SPHK1SPHK2RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL8774121 | 0.91 | SPHK1 (0.56) | SPHK1SPHK2RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL8774147 | 0.89 | SPHK1 (0.35) | SPHK1ACACB | |
| SCHEMBL8774153 | 0.89 | SPHK1 (0.35) | SPHK1ACACB | |
| SCHEMBL9157571 | 0.81 | SPHK1 (0.46) | SPHK1SPHK2ACACB | |
| SCHEMBL9157583 | 0.81 | SPHK1 (0.46) | SPHK1SPHK2ACACB | |
| SCHEMBL8774616 | 0.81 | RAB9A (0.46) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |