Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | VEGFA | P15692 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774317 | 0.93 | SLC6A2 (0.35) | SLC6A2SLC6A4SLC6A3FPR2PROKR1 | |
| SCHEMBL8774197 | 0.92 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3FPR2PROKR1 | |
| SCHEMBL8774253 | 0.91 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3FPR2PROKR1 | |
| SCHEMBL8774193 | 0.91 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3FPR2PROKR1 | |
| SCHEMBL8775244 | 0.90 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3FPR2PROKR1 | |
| SCHEMBL9159138 | 0.86 | AKR1C3 (0.37) | SLC6A2SLC6A4SLC6A3ACACBAKR1C3 | |
| SCHEMBL8774299 | 0.82 | GPR84 (0.36) | MAP4K4AKR1C2 | |
| SCHEMBL8774439 | 0.82 | CYP2C9 (0.45) | — | |
| SCHEMBL8774303 | 0.82 | GPR84 (0.36) | MAP4K4AKR1C2 | |
| SCHEMBL8774447 | 0.82 | CYP2C9 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |