Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774303 | 1.00 | GPR84 (0.36) | GPR84MAOBMAOAMAP4K4AKR1C2 | |
| SCHEMBL8774328 | 0.93 | GPR84 (0.38) | GPR84MAOBMAOAMAP4K4AKR1C2 | |
| SCHEMBL8774323 | 0.93 | GPR84 (0.38) | GPR84MAOBMAOAMAP4K4AKR1C2 | |
| SCHEMBL8774899 | 0.92 | GPR84 (0.36) | GPR84MAOBMAOAMAP4K4KCNH2 | |
| SCHEMBL8774904 | 0.92 | GPR84 (0.36) | GPR84MAOBMAOAMAP4K4KCNH2 | |
| SCHEMBL8774205 | 0.91 | AKR1C2 (0.36) | GPR84MAOBMAOAAKR1C2AKR1C1 | |
| SCHEMBL8774201 | 0.91 | AKR1C2 (0.36) | GPR84MAOBMAOAAKR1C2AKR1C1 | |
| SCHEMBL8774204 | 0.90 | MAPT (0.37) | GPR84AKR1C2AKR1C1HRH3MEN1 | |
| SCHEMBL8774260 | 0.90 | MAPT (0.37) | GPR84AKR1C2AKR1C1HRH3MEN1 | |
| SCHEMBL8774209 | 0.90 | MAPT (0.37) | GPR84AKR1C2AKR1C1HRH3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |