Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774899 | 1.00 | GPR84 (0.36) | GPR84MAOBMAP4K4MAOADGAT1 | |
| SCHEMBL8774303 | 0.92 | GPR84 (0.36) | GPR84MAOBMAP4K4MAOADGAT1 | |
| SCHEMBL8774299 | 0.92 | GPR84 (0.36) | GPR84MAOBMAP4K4MAOADGAT1 | |
| SCHEMBL8774323 | 0.90 | GPR84 (0.38) | GPR84MAOBMAP4K4MAOAMEN1 | |
| SCHEMBL8774328 | 0.90 | GPR84 (0.38) | GPR84MAOBMAP4K4MAOAMEN1 | |
| SCHEMBL8774205 | 0.89 | AKR1C2 (0.36) | GPR84MAOBMAOAMEN1KMT2A | |
| SCHEMBL8774201 | 0.89 | AKR1C2 (0.36) | GPR84MAOBMAOAMEN1KMT2A | |
| SCHEMBL8774209 | 0.88 | MAPT (0.37) | GPR84MEN1KMT2A | |
| SCHEMBL8774204 | 0.88 | MAPT (0.37) | GPR84MEN1KMT2A | |
| SCHEMBL8774260 | 0.88 | MAPT (0.37) | GPR84MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |