Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774375 | 1.00 | MAPT (0.35) | MAPTGAACYP2C9MEN1KMT2A | |
| SCHEMBL8774790 | 0.97 | CYP2C9 (0.35) | MAPTGAACYP2C9MEN1KMT2A | |
| SCHEMBL8774778 | 0.97 | CYP2C9 (0.35) | MAPTGAACYP2C9MEN1KMT2A | |
| SCHEMBL8774022 | 0.92 | CYP2C9 (0.41) | MAPTCYP2C9MEN1KMT2AMAPK1 | |
| SCHEMBL8774015 | 0.92 | CYP2C9 (0.41) | MAPTCYP2C9MEN1KMT2AMAPK1 | |
| SCHEMBL8774743 | 0.91 | MAPT (0.34) | MAPTGAACYP2C9MEN1KMT2A | |
| SCHEMBL8774749 | 0.91 | MAPT (0.34) | MAPTGAACYP2C9MEN1KMT2A | |
| SCHEMBL8774932 | 0.88 | TRPV3 (0.32) | CYP2C9ESR2CYP3A4 | |
| SCHEMBL8774936 | 0.88 | TRPV3 (0.32) | CYP2C9ESR2CYP3A4 | |
| SCHEMBL8775163 | 0.87 | CYP2C9 (0.33) | MAPTGAACYP2C9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |