Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774936 | 1.00 | TRPV3 (0.32) | TRPV3FFAR1EGLN1EGLN3IDO1 | |
| SCHEMBL8774015 | 0.91 | CYP2C9 (0.41) | FFAR1EGLN1EGLN3IDO1CYP2C9 | |
| SCHEMBL8774022 | 0.91 | CYP2C9 (0.41) | FFAR1EGLN1EGLN3IDO1CYP2C9 | |
| SCHEMBL8774514 | 0.90 | FFAR1 (0.31) | TRPV3FFAR1EGLN1EGLN3 | |
| SCHEMBL8774506 | 0.90 | FFAR1 (0.31) | TRPV3FFAR1EGLN1EGLN3 | |
| SCHEMBL8774778 | 0.89 | CYP2C9 (0.35) | FFAR1EGLN1EGLN3CYP2C9ESR2 | |
| SCHEMBL8774790 | 0.89 | CYP2C9 (0.35) | FFAR1EGLN1EGLN3CYP2C9ESR2 | |
| SCHEMBL8774375 | 0.88 | MAPT (0.35) | CYP2C9CYP3A4ESR2 | |
| SCHEMBL8774384 | 0.88 | MAPT (0.35) | CYP2C9CYP3A4ESR2 | |
| SCHEMBL9158040 | 0.84 | CYP2C9 (0.31) | TRPV3EGLN1EGLN3CYP2C9ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |