Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 6/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.33 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774094 | 1.00 | PANK3 (0.38) | PANK3KDM5AKDM4COPRL1USP25 | |
| SCHEMBL8774803 | 0.89 | PANK3 (0.36) | PANK3KDM5AKDM4COPRL1USP25 | |
| SCHEMBL8774794 | 0.89 | PANK3 (0.36) | PANK3KDM5AKDM4COPRL1USP25 | |
| SCHEMBL8774422 | 0.87 | PANK3 (0.35) | PANK3KDM5AKDM4CUSP25 | |
| SCHEMBL8774430 | 0.87 | PANK3 (0.35) | PANK3KDM5AKDM4CUSP25 | |
| SCHEMBL23126972 | 0.86 | OPRL1 (0.40) | PANK3KDM5AKDM4COPRL1KDM1A | |
| SCHEMBL9158916 | 0.86 | PANK3 (0.35) | PANK3KDM5AKDM4COPRL1USP25 | |
| SCHEMBL9158929 | 0.86 | PANK3 (0.35) | PANK3KDM5AKDM4COPRL1USP25 | |
| SCHEMBL8774570 | 0.86 | SPHK1 (0.35) | — | |
| SCHEMBL8774560 | 0.86 | SPHK1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |