Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.40 |
| ▸ | RELA | Q04206 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RARA | P10276 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774371 | 0.96 | RARB (0.48) | RARBRAB9ASMN1; SMN2NFKB1NPC1 | |
| SCHEMBL8774991 | 0.94 | RARB (0.50) | RARBRAB9ASMN1; SMN2NPC1L3MBTL1 | |
| SCHEMBL8774727 | 0.94 | RARB (0.50) | RARBRAB9ASMN1; SMN2NPC1L3MBTL1 | |
| SCHEMBL8774482 | 0.93 | RARB (0.46) | RARBRAB9ASMN1; SMN2NFKB1NPC1 | |
| SCHEMBL8774652 | 0.91 | NPC1 (0.42) | RARBRAB9ASMN1; SMN2NPC1TP53 | |
| SCHEMBL8774382 | 0.89 | RARB (0.51) | RARBRAB9ASMN1; SMN2NFKB1NPC1 | |
| SCHEMBL8774834 | 0.88 | RARB (0.53) | RARBRAB9ASMN1; SMN2NPC1L3MBTL1 | |
| SCHEMBL8774508 | 0.88 | RARB (0.53) | RARBRAB9ASMN1; SMN2NPC1L3MBTL1 | |
| SCHEMBL8774259 | 0.85 | FEN1 (0.40) | RAB9ASMN1; SMN2NPC1MAPK1L3MBTL1 | |
| SCHEMBL8774168 | 0.84 | NPC1 (0.42) | RARBRAB9ASMN1; SMN2NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |