Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 11/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 8/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774798 | 0.92 | FEN1 (0.40) | FEN1ALOX5APPDE3BPDE3AUSP7 | |
| SCHEMBL8774652 | 0.88 | NPC1 (0.42) | FEN1ALOX5APNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8774684 | 0.85 | RARB (0.43) | FEN1ALOX5APNPC1ALDH1A1LMNA | |
| SCHEMBL8774371 | 0.84 | RARB (0.48) | NPC1ALDH1A1MAPTMAPK1RAB9A | |
| SCHEMBL8774727 | 0.83 | RARB (0.50) | NPC1ALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL8774991 | 0.83 | RARB (0.50) | NPC1ALDH1A1LMNAMAPTRAB9A | |
| SCHEMBL8775015 | 0.81 | EGLN1 (0.42) | NPC1LMNARAB9ASMN1; SMN2GRIN2B | |
| SCHEMBL8774747 | 0.81 | EGLN1 (0.42) | NPC1LMNARAB9ASMN1; SMN2GRIN2B | |
| SCHEMBL8774168 | 0.81 | NPC1 (0.42) | FEN1ALOX5APNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9158263 | 0.81 | PDE3B (0.47) | FEN1ALOX5APPDE3BPDE3AUSP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |