Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774634 | 0.97 | KDM4E (0.43) | KDM4EALDH1A1HPGDHTTL3MBTL1 | |
| SCHEMBL8774528 | 0.92 | ACACB (0.42) | KDM4EALDH1A1HPGDHTTL3MBTL1 | |
| SCHEMBL8774215 | 0.85 | ACACB (0.44) | TSHRACACB | |
| SCHEMBL9469637 | 0.82 | NR5A1 (0.47) | KDM4EALDH1A1HPGDHTTL3MBTL1 | |
| SCHEMBL9470198 | 0.82 | NR5A1 (0.51) | KDM4EALDH1A1HPGDHTTL3MBTL1 | |
| SCHEMBL8774719 | 0.82 | HSD17B10 (0.44) | KDM4EALDH1A1HPGDL3MBTL1TP53 | |
| SCHEMBL8774677 | 0.82 | FFAR1 (0.43) | KDM4EALDH1A1HPGDL3MBTL1TSHR | |
| SCHEMBL9470078 | 0.81 | NR5A1 (0.50) | KDM4EALDH1A1HPGDHTTL3MBTL1 | |
| SCHEMBL9470514 | 0.81 | NR5A1 (0.54) | KDM4EALDH1A1HPGDHTTL3MBTL1 | |
| SCHEMBL9470334 | 0.81 | NR5A1 (0.54) | KDM4EALDH1A1HPGDHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |