Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 5/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774460 | 0.96 | HSD17B10 (0.43) | FFAR1PTPN11PTPROTSHRHSD17B10 | |
| SCHEMBL8774719 | 0.94 | HSD17B10 (0.44) | FFAR1PTPN11PTPROTSHRHSD17B10 | |
| SCHEMBL8775133 | 0.92 | HSD17B10 (0.49) | FFAR1TSHRHSD17B10KDM4EMEN1 | |
| SCHEMBL8774897 | 0.91 | FFAR1 (0.45) | FFAR1HSD17B10PKMACACBEGLN1 | |
| SCHEMBL8774819 | 0.87 | FFAR1 (0.43) | FFAR1TSHRHSD17B10MAPTPKM | |
| SCHEMBL8774154 | 0.85 | EGLN1 (0.47) | FFAR1ACACBEGLN1 | |
| SCHEMBL8774634 | 0.84 | KDM4E (0.43) | HSD17B10KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8774700 | 0.82 | KDM4E (0.47) | TSHRHSD17B10KDM4EALDH1A1LMNA | |
| SCHEMBL8774517 | 0.81 | EGLN1 (0.44) | FFAR1ACACBEGLN1 | |
| SCHEMBL9158558 | 0.81 | GRM5 (0.46) | FFAR1PTPN11PTPROTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |