SCHEMBL8774884

SCHEMBL8774884

Cc1ccc(Nc2ccccc2/C=C/c2ccccc2/C=C/c2ccccc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
PTGS2 P35354 1/20 0.49
GAA P10253 1/20 0.49
MAPT P10636 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
HPGD P15428 1/20 0.48
FGF23 Q9GZV9 1/20 0.47
NFE2L2 Q16236 4/20 0.47
SIRT2 Q8IXJ6 1/20 0.47
EGFR P00533 1/20 0.45
MMP1 P03956 1/20 0.45
MMP2 P08253 1/20 0.45
MMP9 P14780 1/20 0.45
SIGMAR1 Q99720 1/20 0.44
ALDH1A1 P00352 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
TRPA1 O75762 2/20 0.41
SNCA P37840 1/20 0.40
ATP4A P20648 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5551231 0.98 NPC1 (0.53) NPC1RAB9APTGS2GAAMAPT
SCHEMBL5551227 0.98 NPC1 (0.53) NPC1RAB9APTGS2GAAMAPT
SCHEMBL2494333 0.88 SIRT2 (0.57) GAAMAPTTDP1NFE2L2SIRT2
SCHEMBL5141674 0.86 NPC1 (0.47) NPC1RAB9APTGS2GAAMAPT
SCHEMBL8774892 0.86 NPC1 (0.47) NPC1RAB9APTGS2GAAMAPT
SCHEMBL2498783 0.86 SIRT2 (0.50) PTGS2GAAMAPTTDP1HPGD
SCHEMBL15900063 0.81 GAA (0.44) NPC1RAB9APTGS2GAAMAPT
SCHEMBL10128973 0.81 HPGD (0.68) NPC1RAB9APTGS2GAAMAPT
SCHEMBL12700847 0.81 HPGD (0.68) NPC1RAB9APTGS2GAAMAPT
SCHEMBL7164325 0.80 NFE2L2 (0.68) MAPTHPGDFGF23NFE2L2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0278757-B1 Electroluminescent device with improved cathode EASTMAN KODAK CO (US) 1997-11-12 EP disclosed
EP-0278758-B1 ELECTROLUMINESCENT DEVICE WITH ORGANIC LUMINESCENT MEDIUM EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1993-03-31 EP disclosed
EP-0281381-B1 ELECTROLUMINESCENT DEVICE WITH MODIFIED THIN FILM LUMINESCENT ZONE EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1992-07-15 EP disclosed
EP-0349265-A2 Electroluminescent devices EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1990-01-03 EP disclosed