Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.42 |
| ▸ | ASPH | Q12797 | 6/20 | 0.42 |
| ▸ | KDM8 | Q8N371 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zinc Ion SCHEMBL31231815 | 0.82 | GABRA1 (0.39) | KDM4EMAPTCYP1A2GABRA1GABRB2 | |
| Zinc Ion SCHEMBL31231816 | 0.82 | GABRA1 (0.39) | KDM4EMAPTCYP1A2GABRA1GABRB2 | |
| SCHEMBL29099630 | 0.79 | KDM4E (0.44) | KDM4EMAPTCYP1A2GABRA1GABRB2 | |
| SCHEMBL5820837 | 0.79 | KDM4E (0.44) | KDM4EMAPTCYP1A2GABRA1GABRB2 | |
| SCHEMBL868001 | 0.79 | KDM4E (0.44) | KDM4EMAPTCYP1A2GABRA1GABRB2 | |
| SCHEMBL10694897 | 0.79 | KDM4E (0.47) | KDM4EMAPTCYP1A2GABRA1GABRB2 | |
| SCHEMBL30998328 | 0.78 | KDM4E (0.43) | KDM4EMAPTCYP1A2GABRA1GABRB2 | |
| SCHEMBL8645026 | 0.78 | KDM4E (0.46) | KDM4EMAPTCYP1A2GABRA1GABRB2 | |
| SCHEMBL480290 | 0.77 | KDM4E (0.40) | KDM4EMAPTCYP1A2GABRA1GABRB2 | |
| SCHEMBL5818329 | 0.76 | KDM4E (0.47) | KDM4EMAPTCYP1A2GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0598093-B1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHETASE INHIBITORS | ZENECA LTD (GB) | 1997-11-19 | — | — | EP | disclosed |
| US-5554613-A | QUINUCLIDINE DERIVATIVES, QUALENE SYNTHASE INHIBITORS, TREATMENT OF HYPERCHOLESTEROLEMIA, ATHEROSCLEROSIS AND FUNGUS INFECTIONS | ZENECA LIMITED (GB) | 1996-09-10 | — | — | US | disclosed |
| EP-0598093-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHETASE INHIBITORS | ZENECA LIMITED (GB) | 1994-05-25 | — | — | EP | disclosed |
| WO-1993024486-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHETASE INHIBITORS | ZENECA LIMITED (GB) | 1993-12-09 | — | — | WO | disclosed |