SCHEMBL8775303

SCHEMBL8775303

c1ccc2nc(-c3nccs3)cnc2c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.65
NPC1 O15118 6/20 0.57
HPGD P15428 2/20 0.57
SMN1; SMN2 Q16637 2/20 0.57
ALDH1A1 P00352 2/20 0.57
MAPK10 P53779 2/20 0.57
KDM4E B2RXH2 2/20 0.57
GAA P10253 1/20 0.57
CASP1 P29466 1/20 0.57
CASP7 P55210 1/20 0.57
HSD17B10 Q99714 1/20 0.57
BCHE P06276 1/20 0.50
PDPK1 O15530 1/20 0.48
HSP90AA1 P07900 2/20 0.46
CYP1A2 P05177 1/20 0.45
PDE10A Q9Y233 1/20 0.44
ADORA3 P0DMS8 2/20 0.44
ADORA2A P29274 1/20 0.44
ADORA1 P30542 1/20 0.44
CYP2A6 P11509 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5792282 0.79 RAB9A (1.00) RAB9ANPC1HPGDSMN1; SMN2ALDH1A1
SCHEMBL29942654 0.76 NPC1 (0.63) RAB9ANPC1HPGDSMN1; SMN2ALDH1A1
SCHEMBL29614829 0.76 NPC1 (0.63) RAB9ANPC1HPGDSMN1; SMN2ALDH1A1
SCHEMBL29966674 0.76 NPC1 (0.63) RAB9ANPC1HPGDSMN1; SMN2ALDH1A1
SCHEMBL3076524 0.76 NPC1 (0.63) RAB9ANPC1HPGDSMN1; SMN2ALDH1A1
SCHEMBL15418064 0.76 RAB9A (0.56) RAB9AHPGDSMN1; SMN2ALDH1A1KDM4E
SCHEMBL30189727 0.76 HPGD (0.45) RAB9ANPC1HPGDSMN1; SMN2ALDH1A1
SCHEMBL13801161 0.74 NPC1 (0.51) RAB9ANPC1HPGDSMN1; SMN2ALDH1A1
SCHEMBL31393433 0.73 NPC1 (1.00) RAB9ANPC1HPGDSMN1; SMN2ALDH1A1
SCHEMBL708998 0.73 NPC1 (1.00) RAB9ANPC1HPGDSMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0794951-A1 PROCESSES AND INTERMEDIATES FOR PREPARING CIS(+)3- 4,-6-DIHYDROXYCHROMAN-3-YLMETHYL]-4-METHOXYANILINE Pfizer Hospital Products Group, Inc. (US) 1997-09-17 EP disclosed
WO-1996016955-A1 PROCESSES AND INTERMEDIATES FOR PREPARING CIS(+)3-[4,-6-DIHYDROXYCHROMAN-3-YLMETHYL]-4-METHOXYANILINE PFIZER INC. (US) 1996-06-06 WO disclosed