Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.46 |
| ▸ | TRPC5 | Q9UL62 | 7/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15973191 | 0.80 | KMT2A (0.58) | KMT2AMEN1SMN1; SMN2MAPTP2RX7 | |
| SCHEMBL7252823 | 0.78 | GSK3A (0.57) | KMT2AMEN1HRH3 | |
| SCHEMBL4514612 | 0.76 | GSK3B (0.60) | KMT2AMEN1SMN1; SMN2MAPTP2RX7 | |
| SCHEMBL20818195 | 0.76 | KMT2A (0.66) | KMT2AMEN1SMN1; SMN2MAPTP2RX7 | |
| SCHEMBL16085665 | 0.75 | GSK3A (0.54) | KMT2AMEN1HRH3 | |
| SCHEMBL19231674 | 0.74 | KMT2A (0.46) | KMT2AMEN1SMN1; SMN2MAPTP2RX7 | |
| SCHEMBL20578249 | 0.74 | KMT2A (0.46) | KMT2AMEN1SMN1; SMN2MAPTP2RX7 | |
| SCHEMBL3120511 | 0.74 | BCHE (0.52) | KMT2AMEN1SMN1; SMN2MAPTLMNA | |
| SCHEMBL4517013 | 0.73 | KMT2A (1.00) | KMT2AMEN1SMN1; SMN2MAPTP2RX7 | |
| SCHEMBL7179194 | 0.72 | OPRK1 (0.35) | KMT2AMEN1SMN1; SMN2MAPTHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643000-A2 | THERAPEUTIC PIPERAZINES | Dart Neuroscience (Cayman) Ltd (KY) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012040258-A2 | THERAPEUTIC PIPERAZINES | HELICON THERAPEUTICS, INC. (US) | 2012-03-29 | — | — | WO | disclosed |