Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | TRPC5 | Q9UL62 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9871553 | 0.81 | LMNA (0.58) | KMT2AMEN1SMN1; SMN2MAPTP2RX7 | |
| SCHEMBL8633466 | 0.80 | CYP1A2 (0.50) | KMT2AMEN1SMN1; SMN2MAPTP2RX7 | |
| SCHEMBL6938726 | 0.80 | EPHX2 (0.42) | KMT2AMEN1SMN1; SMN2MAPTP2RX7 | |
| SCHEMBL11570834 | 0.80 | MPO (0.49) | EPHX2DDB1CRBNKDM4EPOLB | |
| SCHEMBL7696982 | 0.80 | EPHX2 (0.39) | KMT2AMEN1SMN1; SMN2MAPTTRPC5 | |
| SCHEMBL877544 | 0.80 | KMT2A (0.57) | KMT2AMEN1SMN1; SMN2MAPTP2RX7 | |
| SCHEMBL8128225 | 0.78 | DAO (0.48) | MAPTACHEPOLB | |
| SCHEMBL4512688 | 0.75 | KMT2A (0.65) | KMT2AMEN1SMN1; SMN2MAPTP2RX7 | |
| SCHEMBL9850086 | 0.75 | DDB1 (0.69) | KMT2AMEN1EPHX2DDB1CRBN | |
| SCHEMBL1011633 | 0.75 | DDB1 (0.69) | KMT2AMEN1EPHX2DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2958897-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | Senomyx, Inc. (US) | 2015-12-30 | — | — | EP | disclosed |
| WO-2014130582-A2 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. (US) | 2014-08-28 | — | — | WO | disclosed |