Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | STS | P08842 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5679460 | 0.90 | AKR1C3 (0.58) | AKR1C3TSHRMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL9830530 | 0.84 | HSD17B10 (0.51) | AKR1C3TSHRMAPK1HSD17B10LMNA | |
| SCHEMBL8776090 | 0.83 | AKR1C3 (0.79) | AKR1C3TSHRMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL8775986 | 0.83 | CYP3A4 (0.54) | AKR1C3HSD17B10SMN1; SMN2LMNAESR1 | |
| SCHEMBL8775742 | 0.82 | ESR1 (0.52) | AKR1C3HSD17B10SMN1; SMN2LMNAESR1 | |
| SCHEMBL5191077 | 0.80 | LMNA (0.52) | AKR1C3TSHRMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL14558089 | 0.80 | LMNA (0.52) | AKR1C3TSHRMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL8986623 | 0.75 | HSD17B10 (0.53) | AKR1C3TSHRMAPK1HSD17B10LMNA | |
| SCHEMBL8775793 | 0.75 | AKR1C3 (0.49) | AKR1C3TSHRMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL9747578 | 0.74 | AKR1C3 (0.77) | AKR1C3TSHRMAPK1HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0719276-B1 | ORALLY ACTIVE DERIVATIVES OF 1,3,5(10)-ESTRATRIENE | US HEALTH (US) | 1997-11-26 | — | — | EP | disclosed |
| US-5554603-A | 11,17-DINITRATES; USE TO ACHIEVE ESTROGENIC EFFECT IN FEMALE MAMMALS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1996-09-10 | — | — | US | disclosed |
| WO-1995007925-A1 | ORALLY ACTIVE DERIVATIVES OF 1,3,5(10)-ESTRATRIENE | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1995-03-23 | — | — | WO | disclosed |
| US-RE34136-E | Morning-after contraceptives | SRI INTERNATIONAL (US) | 1992-12-01 | — | — | US | disclosed |
| US-4705783-A | 9α, 11β-substituted and 11β-substituted estranes | SRI INTERNATIONAL (US) | 1987-11-10 | — | — | US | disclosed |
| WO-1987000175-A1 | 9alpha, 11beta-SUBSTITUTED AND 11beta-SUBSTITUTED ESTRANES | SRI INTERNATIONAL (US) | 1987-01-15 | — | — | WO | disclosed |