Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | SHBG | P04278 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 2/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.49 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8986623 | 0.91 | HSD17B10 (0.53) | HSD17B10AKR1C3TSHRMAPK1MEN1 | |
| SCHEMBL1889441 | 0.88 | HSD17B10 (0.50) | HSD17B10AKR1C3TSHRMAPK1MEN1 | |
| SCHEMBL13804515 | 0.88 | HSD17B10 (0.50) | HSD17B10AKR1C3TSHRMAPK1MEN1 | |
| SCHEMBL8775995 | 0.84 | AKR1C3 (0.58) | HSD17B10AKR1C3TSHRMAPK1MEN1 | |
| Almestrone SCHEMBL12364585 | 0.82 | CYP19A1 (0.65) | HSD17B10CYP19A1HSD17B1CYP3A4SHBG | |
| Almestrone SCHEMBL8089798 | 0.82 | CYP19A1 (0.65) | HSD17B10CYP19A1HSD17B1CYP3A4SHBG | |
| Almestrone SCHEMBL13216952 | 0.82 | CYP19A1 (0.65) | HSD17B10CYP19A1HSD17B1CYP3A4SHBG | |
| Almestrone SCHEMBL1657631 | 0.82 | CYP19A1 (0.65) | HSD17B10CYP19A1HSD17B1CYP3A4SHBG | |
| Almestrone SCHEMBL12364346 | 0.82 | CYP19A1 (0.65) | HSD17B10CYP19A1HSD17B1CYP3A4SHBG | |
| Almestrone SCHEMBL5983577 | 0.82 | CYP19A1 (0.65) | HSD17B10CYP19A1HSD17B1CYP3A4SHBG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227813-B1 | 11-BETA-NITRATE-SUBSTITUTED ESTRANES | SRI INTERNATIONAL (US) | 1991-10-02 | — | — | EP | disclosed |