SCHEMBL8776014

SCHEMBL8776014

CC(C)Nc1ccc(Cl)cc1N

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.47
ALDH1A1 P00352 5/20 0.46
TSHR P16473 3/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
ALOX15 P16050 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
TP53 P04637 2/20 0.45
HPGD P15428 2/20 0.42
ALOX12 P18054 1/20 0.42
MAPK1 P28482 1/20 0.42
HSD17B10 Q99714 1/20 0.42
HDAC1 Q13547 1/20 0.42
GAA P10253 2/20 0.41
KMT2A Q03164 2/20 0.41
ABL1 P00519 1/20 0.41
NR4A2 P43354 1/20 0.39
LMNA P02545 2/20 0.38
HTT P42858 2/20 0.38
APP P05067 1/20 0.38
KDM4E B2RXH2 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2157691 0.79 CA1 (0.55) ALDH1A1TSHRSMN1; SMN2TP53HPGD
SCHEMBL15176894 0.79 CRHBP (0.43) CYP3A4ALDH1A1HPGDMAPK1KMT2A
SCHEMBL7358360 0.78 CA14 (0.50) CYP3A4ALDH1A1TSHRSMN1; SMN2ALOX15
Ammonia Solution, Strong SCHEMBL3235802 0.78 CA1 (0.53) ALDH1A1TSHRSMN1; SMN2TP53HPGD
SCHEMBL3634659 0.78 TDP1 (0.48) CYP3A4ALDH1A1TSHRSMN1; SMN2ALOX15
SCHEMBL13831247 0.78 NOX1 (0.50) ALDH1A1SMN1; SMN2ALOX12MAPK1GAA
SCHEMBL1980735 0.77 ALDH1A1 (0.53) CYP3A4ALDH1A1TSHRSMN1; SMN2ALOX15
SCHEMBL29703904 0.77 ALDH1A1 (0.53) CYP3A4ALDH1A1TSHRSMN1; SMN2ALOX15
SCHEMBL14272821 0.76 NR4A2 (0.42) ALDH1A1SMN1; SMN2ALOX15TP53HPGD
SCHEMBL14364963 0.76 MEN1 (0.42) ALDH1A1TSHRTDP1TP53HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0641784-B1 BENZIMIDAZOLE DERIVATIVE, PRODUCTION THEREOF, ANTIEMETIC CONTAINING SAME AS ACTIVE INGREDIENT, AND INTERMEDIATE FOR PRODUCING SAME KANEBO LTD (JP) 1997-11-19 EP disclosed
US-5407936-A For vomiting due to chemotherapy with cisplatin KANEBO LTD. (JP) 1995-04-18 US disclosed
EP-0641784-A1 BENZIMIDAZOLE DERIVATIVE, PRODUCTION THEREOF, ANTIEMETIC CONTAINING SAME AS ACTIVE INGREDIENT, AND INTERMEDIATE FOR PRODUCING SAME KANEBO, LTD. (JP) 1995-03-08 EP disclosed