Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.61 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16596173 | 0.84 | ITGB3 (0.62) | MAPTLMNANPSR1ITGB3ITGA2B | |
| SCHEMBL8776254 | 0.83 | SMN1; SMN2 (0.51) | ITGB3ITGA2BSMN1; SMN2 | |
| SCHEMBL13801421 | 0.81 | MAPT (0.58) | MAPTLMNANPSR1ITGB3ITGA2B | |
| SCHEMBL7368202 | 0.81 | ITGB3 (0.67) | MAPTLMNANPSR1ITGB3ITGA2B | |
| SCHEMBL6600563 | 0.81 | MAPT (0.62) | MAPTLMNANPSR1ITGB3ITGA2B | |
| SCHEMBL4377713 | 0.79 | ITGB3 (0.54) | MAPTLMNANPSR1ITGB3ITGA2B | |
| SCHEMBL7787428 | 0.79 | ITGB3 (0.60) | MAPTLMNANPSR1ITGB3ITGA2B | |
| SCHEMBL8543870 | 0.79 | ITGB3 (0.53) | MAPTLMNANPSR1ITGB3ITGA2B | |
| SCHEMBL7791914 | 0.78 | ITGB3 (0.61) | MAPTLMNANPSR1ITGB3ITGA2B | |
| SCHEMBL7790343 | 0.77 | ITGB3 (0.69) | MAPTLMNANPSR1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808311-A2 | NEW DERIVATIVES OF PYRIDIL PIPERAZINE OR PYRIDAZINYL PIPERAZYL, PROCESS FOR PRODUCTION THEREOF AND MEDICAMENTS CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024581-A2 | DERIVATIVES OF PYRIDIL PIPERAZINE OR PYRIDAZINYL PIPERAZYL, PROCESS FOR PRODUCTION THEREOF AND MEDICAMENTS CONTAINING THESE COMPOUNDS | BOEHRINGER MANNHEIM GMBH (DE) | 1996-08-15 | — | — | WO | disclosed |