SCHEMBL8776517

SCHEMBL8776517

C=C([SiH3])C(N(C(=C)C)C(C)=O)N(C(=C)C)C(C)=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2519220 0.73
SCHEMBL11377300 0.60
SCHEMBL9818007 0.58 CHRM2 (0.39)
SCHEMBL7884699 0.58 CHRM2 (0.39)
SCHEMBL21496513 0.58 CHRM2 (0.39)
SCHEMBL3740401 0.58 TDP1 (0.37)
SCHEMBL18073627 0.58
SCHEMBL707599 0.58
SCHEMBL24054924 0.57 CA1 (0.43)
SCHEMBL134849 0.57

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0577336-B1 Two-part, ultra-low modulus silicone sealant DOW CORNING (US) 1997-12-03 EP disclosed
EP-0457264-B1 Two-part, ultra low modulus silicone sealant DOW CORNING (US) 1996-06-05 EP disclosed
EP-0415596-B1 Silicone sealants DOW CORNING (US) 1995-12-06 EP disclosed
US-5290826-A Storage stable seal curable at room temperature DOW CORNING CORPORATION (US) 1994-03-01 US disclosed
EP-0337764-B1 Asphalt highway joint sealant DOW CORNING (US) 1994-01-05 EP disclosed
EP-0577336-A2 Two-part, ultra-low modulus silicone sealant DOW CORNING CORPORATION (US) 1994-01-05 EP disclosed
US-5246980-A Anhydrous endblocked polysiloxane, diacetamidosilane chain extender and eminoxysilicone compound crosslinker in first part; endbocked polysiloxanes in second part DOW CORNING CORPORATION (US) 1993-09-21 US disclosed
EP-0542471-A1 High strength fluorosilicone rubber DOW CORNING CORPORATION (US) 1993-05-19 EP disclosed
US-5171773-A Reacting hydroxy endblocked trifluoropropylmethylsiloxane with methylvinyldi(N-alkylacetamido)silane, mixing formed polymer with copolymer of methylvinylsiloxane and dimethylsiloxane, fuming silica and peroxide catalyst, curing DOW CORNING CORPORATION (US) 1992-12-15 US disclosed
EP-0337792-B1 FLOWABLE JOINT SEALANT FOR CONCRETE HIGHWAY DOW CORNING CORPORATION (US) 1992-06-03 EP disclosed
EP-0457264-A2 Two-part, ultra low modulus silicone sealant DOW CORNING CORPORATION (US) 1991-11-21 EP disclosed
US-5017628-A Self-leveling polysiloxane DOW CORNING CORPORATION (US) 1991-05-21 US disclosed
EP-0415596-A1 Silicone sealants DOW CORNING CORPORATION (US) 1991-03-06 EP disclosed
US-4978706-A MOISTURE CURABLE DOW CORNING CORPORATION (US) 1990-12-18 US disclosed
US-4889878-A SELF-LEVELING, MOISTURE CURABLE POLYSILOXANES; FILLERS, DIAMIDOVINYL SILANES, AMINOXYSILANES DOW CORNING CORPORATION (US) 1989-12-26 US disclosed
EP-0337764-A2 Asphalt highway joint sealant DOW CORNING CORPORATION (US) 1989-10-18 EP disclosed
EP-0337792-A2 Flowable joint sealant for concrete highway DOW CORNING CORPORATION (US) 1989-10-18 EP disclosed