Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.58 |
| ▸ | RAB9A | P51151 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | IKBKB | O14920 | 5/20 | 0.50 |
| ▸ | CASP3 | P42574 | 2/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6229303 | 0.87 | MAPT (0.67) | MAPTRAB9AMEN1KMT2AKDM4E | |
| SCHEMBL6610018 | 0.83 | IKBKB (0.64) | MAPTRAB9AMEN1KMT2AKDM4E | |
| SCHEMBL875026 | 0.83 | MAPT (0.53) | MAPTRAB9AMEN1KMT2AKDM4E | |
| SCHEMBL7055593 | 0.79 | MAPT (0.52) | MAPTRAB9AMEN1KMT2AKDM4E | |
| SCHEMBL4354866 | 0.73 | MAPT (1.00) | MAPTRAB9AMEN1KMT2AKDM4E | |
| SCHEMBL6607594 | 0.72 | MAPT (0.69) | MAPTRAB9AMEN1KMT2AKDM4E | |
| SCHEMBL30816304 | 0.70 | APP (0.60) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL10070140 | 0.69 | MAPT (0.78) | MAPTRAB9AMEN1KMT2AKDM4E | |
| SCHEMBL5195941 | 0.68 | KDM4E (0.76) | MAPTRAB9AMEN1KMT2AKDM4E | |
| SCHEMBL5370617 | 0.68 | MAPT (0.76) | MAPTRAB9AMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |