Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.47 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.47 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6229303 | 0.84 | MAPT (0.67) | MAPTRAB9AMEN1KMT2AKDM4E | |
| SCHEMBL875026 | 0.83 | MAPT (0.53) | MAPTRAB9AMEN1KMT2AKDM4E | |
| SCHEMBL6610018 | 0.83 | IKBKB (0.64) | MAPTRAB9AMEN1KMT2AKDM4E | |
| SCHEMBL7052069 | 0.81 | IKBKB (0.55) | RAB9AMEN1KMT2AALDH1A1IKBKB | |
| SCHEMBL874783 | 0.80 | IKBKB (0.48) | MAPTRAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL7055446 | 0.80 | IKBKB (0.72) | MAPTRAB9AMEN1KMT2AKDM4E | |
| SCHEMBL877661 | 0.79 | MAPT (0.58) | MAPTRAB9AMEN1KMT2AKDM4E | |
| SCHEMBL7052936 | 0.74 | IKBKB (0.69) | MAPTRAB9AMEN1KMT2AKDM4E | |
| SCHEMBL7057778 | 0.74 | TUBB4A (0.65) | MAPTRAB9AMEN1KMT2AKDM4E | |
| SCHEMBL18837900 | 0.74 | MAPT (0.58) | MAPTMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028731-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |