Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 5/20 | 0.52 |
| ▸ | CA2 | P00918 | 5/20 | 0.52 |
| ▸ | CA9 | Q16790 | 5/20 | 0.52 |
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ME2 | P23368 | 1/20 | 0.49 |
| ▸ | ME1 | P48163 | 1/20 | 0.49 |
| ▸ | ME3 | Q16798 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27498807 | 0.92 | GAA (0.51) | GAACA12CA2CA9CA1 | |
| SCHEMBL8776675 | 0.89 | POLB (0.50) | POLBNAMPTCCR2KCNH2CYP2D6 | |
| SCHEMBL8776666 | 0.88 | POLB (0.67) | GAAPOLBNAMPTCCR2CYP2D6 | |
| Hydrochloric Acid SCHEMBL9057311 | 0.84 | POLB (0.51) | POLBNAMPTCCR2KCNH2CYP2D6 | |
| SCHEMBL4391646 | 0.82 | POLB (0.71) | GAACA12CA2CA9CA1 | |
| SCHEMBL9058915 | 0.81 | MAPT (0.46) | POLBCCR2MAPT | |
| SCHEMBL14413284 | 0.81 | CYP3A4 (0.68) | GAACA12CA2CA9CA1 | |
| Hydrochloric Acid SCHEMBL9059017 | 0.80 | MAPT (0.45) | POLBNAMPTCCR2CYP2D6CYP3A4 | |
| SCHEMBL27485389 | 0.79 | GAA (0.51) | GAACA12CA2CA9CA1 | |
| SCHEMBL27484675 | 0.79 | L3MBTL3 (0.64) | POLBL3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1183770-A | Piperazine derivatives, medicaments containing these compounds, their use and processes for their preparation | THOMAE GMBH DR K (DE) | 1998-06-03 | — | — | CN | claimed |
| CN-1183770-A | Piperazine derivatives, medicaments containing these compounds, their use and processes for their preparation | THOMAE GMBH DR K (DE) | 1998-06-03 | — | — | CN | disclosed |
| EP-0799202-A1 | PIPERAZINE DERIVATIVES, MEDICAMENTS CONTAINING THE SAME, THEIR USE AND PROCESS FOR PREPARING THE SAME | Dr. Karl Thomae GmbH (DE) | 1997-10-08 | — | — | EP | disclosed |