Phosphoric Acid

Phosphoric Acid

SCHEMBL8776747

Nc1ccc(O)c2ccccc12.O=P(O)(O)O

nearest known ligand 0.79

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Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 5/20 0.79
EP300 Q09472 4/20 0.79
KAT8 Q9H7Z6 4/20 0.79
KAT2B Q92831 3/20 0.79
HDAC3 O15379 1/20 0.79
NCOR2 Q9Y618 1/20 0.79
LDHA P00338 1/20 0.47
HSP90AA1 P07900 1/20 0.44
HSP90AB1 P08238 1/20 0.44
PSMB5 P28074 1/20 0.44
HPGD P15428 2/20 0.42
TDP1 Q9NUW8 2/20 0.42
TSHR P16473 2/20 0.42
ALDH1A1 P00352 1/20 0.42
CYP3A4 P08684 1/20 0.42
HSD17B10 Q99714 1/20 0.42
CTSB P07858 1/20 0.41
MEN1 O00255 1/20 0.40
POLB P06746 1/20 0.40
PABPC1 P11940 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL367092 0.89 IDO1 (1.00) IDO1EP300KAT8KAT2BHDAC3
SCHEMBL29633643 0.89 IDO1 (1.00) IDO1EP300KAT8KAT2BHDAC3
SCHEMBL8003457 0.89 IDO1 (1.00) IDO1EP300KAT8KAT2BHDAC3
Hydrochloric Acid SCHEMBL295131 0.87 IDO1 (0.95) IDO1EP300KAT8KAT2BHDAC3
1-Naphthol SCHEMBL6245547 0.75 CYP1A2 (0.71) IDO1EP300KAT8KAT2BHDAC3
SCHEMBL8386304 0.75 IDO1 (0.48) IDO1EP300KAT8KAT2BHDAC3
SCHEMBL485855 0.75 IDO1 (0.73) IDO1EP300KAT8KAT2BHDAC3
SCHEMBL8371459 0.75 IDO1 (0.73) IDO1EP300KAT8KAT2BHDAC3
SCHEMBL29393764 0.75 IDO1 (0.73) IDO1EP300KAT8KAT2BHDAC3
SCHEMBL29702452 0.75 IDO1 (0.73) IDO1EP300KAT8KAT2BHDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0810435-A2 Detectable molecules, method of preparation and use ENZO BIOCHEM, INC. (US) 1997-12-03 EP disclosed
US-5175269-A Labeled diagnostic and therapeutic agents ENZO DIAGNOSTICS, INC. (US) 1992-12-29 US disclosed
US-5013831-A Medical diagnosis, therapy ENZO BIOCHEM, INC. (US) 1991-05-07 US disclosed
US-5002885-A Detectable molecules, method preparation and use ENZO BIOCHEM, INC. (US) 1991-03-26 US disclosed
US-4952685-A CARRYING A METAL COMPLEXING OR BIOTIN DETECTABLE GROUPS; NUCLEOTIDES ENZO BIOCHEM, INC. (US) 1990-08-28 US disclosed
US-4943523-A METAL CHELATING GROUPS OR BIOTIN ATTACHED TO POLYSACCHARIDES, POLYPEPTIDES, POLYNUCLEOTIDES OR SYNTHETIC POLYMERS; IMMUNOASSAY IMAGING ENZO BIOCHEM, INC. (US) 1990-07-24 US disclosed
US-4849208-A Detectable molecules, method of preparation and use ENZO BIOCHEM, INC. (US) 1989-07-18 US disclosed
US-4849505-A Detectable molecules, method of preparation and use ENZO BIOCHEM, INC. (US) 1989-07-18 US disclosed
US-4843122-A COUPLING AGENT BETWEEN BIOPOLYMER AND CHELATE AGENT OR BIOTIN ENZO BIOCHEM, INC. (US) 1989-06-27 US disclosed
US-4707440-A BIOPOLYMER LINKED TO A CHELATING AGENT BASED ON AN O-CYCLOHEXADIAMINEDIACETIC ACID ENZO BIOCHEM, INC. (US) 1987-11-17 US disclosed
EP-0154788-A2 Detectable molecules, method of preparation and use ENZO BIOCHEM, INC. (US) 1985-09-18 EP disclosed