Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | FNTA | P49354 | 3/20 | 0.45 |
| ▸ | FNTB | P49356 | 3/20 | 0.45 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034458 | 0.84 | MAOB (0.51) | FNTAFNTBPGGT1BLTA4HMAOB | |
| SCHEMBL3803808 | 0.79 | NPC1 (0.43) | CYP11B2SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL3432978 | 0.79 | NPC1 (0.43) | CYP11B2SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL564714 | 0.79 | HPGD (0.43) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL15831937 | 0.78 | HDAC1 (0.48) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL3082319 | 0.78 | ALDH1A1 (0.48) | CYP19A1SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL6957296 | 0.77 | FNTA (0.52) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL3589251 | 0.76 | HPGD (0.47) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD | |
| SCHEMBL11370703 | 0.76 | KDM4E (0.56) | FNTAFNTBPGGT1BSMN1; SMN2MAOB | |
| SCHEMBL20645596 | 0.75 | HPGD (0.46) | SMN1; SMN2NPC1RAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |