SCHEMBL20645596

SCHEMBL20645596

CCCCCCOc1ncccc1C#N

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 6/20 0.46
ALDH1A1 P00352 5/20 0.46
L3MBTL1 Q9Y468 3/20 0.46
NPC1 O15118 1/20 0.46
CASP3 P42574 1/20 0.46
RAB9A P51151 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
SENP8 Q96LD8 1/20 0.46
SENP7 Q9BQF6 1/20 0.46
SENP6 Q9GZR1 1/20 0.46
FAAH O00519 1/20 0.42
MGLL Q99685 1/20 0.42
KDM4E B2RXH2 3/20 0.42
HTT P42858 1/20 0.42
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3589251 0.98 HPGD (0.47) HPGDALDH1A1L3MBTL1NPC1CASP3
SCHEMBL3082319 0.94 ALDH1A1 (0.48) HPGDALDH1A1L3MBTL1NPC1CASP3
SCHEMBL564714 0.89 HPGD (0.43) HPGDALDH1A1L3MBTL1NPC1CASP3
SCHEMBL7430771 0.84 KDM4E (0.40) ALDH1A1KDM4ECYP1A2CYP3A4CYP2D6
SCHEMBL30464563 0.84 USP2 (0.43) HPGDALDH1A1L3MBTL1NPC1CASP3
SCHEMBL3803808 0.82 NPC1 (0.43) HPGDALDH1A1L3MBTL1NPC1CASP3
SCHEMBL249966 0.82 L3MBTL1 (0.49) HPGDALDH1A1L3MBTL1NPC1CASP3
SCHEMBL13310628 0.80 SSTR4 (0.43) HPGDALDH1A1L3MBTL1NPC1CASP3
SCHEMBL3432978 0.79 NPC1 (0.43) HPGDALDH1A1L3MBTL1NPC1RAB9A
SCHEMBL15831911 0.77 ALDH1A1 (0.47) HPGDALDH1A1L3MBTL1KDM4EHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3652167-B1 SPIROHEPTANYL HYDANTOINS AS ROCK INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2021-06-02 EP disclosed
WO-2019014303-A1 FIVE MEMBERED-AMINOHETEROCYCLIC AND 5,6-OR 6,6-MEMBERED BICYCLIC AMINOHETEROCYCLIC INHIBITORS OF ROCK FOR THE TREATMENT OF HEART FAILURE BRISTOL-MYERS SQUIBB COMPANY (US) 2019-01-17 WO disclosed