Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | MGMT | P16455 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034458 | 0.90 | MAOB (0.51) | MAOBCYP3A4SQORFNTAFNTB | |
| SCHEMBL8808187 | 0.80 | ABCB1 (0.53) | MKNK1MKNK2XDHCYP3A4ABCB1 | |
| SCHEMBL15831936 | 0.78 | HDAC1 (0.52) | MKNK1MKNK2XDHMGMT | |
| SCHEMBL249966 | 0.77 | L3MBTL1 (0.49) | CYP1A2CYP3A4CYP2D6CYP2C9HPGD | |
| SCHEMBL3660182 | 0.77 | NPC1 (0.41) | CYP1A2CYP3A4CYP2D6CYP2C9HPGD | |
| SCHEMBL8784748 | 0.75 | ABCB1 (0.58) | XDHCYP3A4ABCB1FNTAFNTB | |
| SCHEMBL2526961 | 0.75 | SLC6A4 (0.46) | MKNK1MKNK2XDHMGMT | |
| SCHEMBL3432978 | 0.75 | NPC1 (0.43) | CYP1A2CYP3A4CYP2D6CYP2C9HPGD | |
| SCHEMBL564714 | 0.75 | HPGD (0.43) | CYP1A2CYP3A4CYP2D6CYP2C9HPGD | |
| SCHEMBL3803808 | 0.75 | NPC1 (0.43) | CYP1A2CYP3A4CYP2D6CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |