Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3432978 | 0.86 | NPC1 (0.43) | NPC1RAB9ASSTR4L3MBTL1GAA | |
| SCHEMBL3803808 | 0.86 | NPC1 (0.43) | NPC1RAB9ASSTR4L3MBTL1GAA | |
| SCHEMBL249966 | 0.81 | L3MBTL1 (0.49) | NPC1RAB9ASSTR4L3MBTL1GAA | |
| SCHEMBL564714 | 0.79 | HPGD (0.43) | NPC1RAB9ASSTR4L3MBTL1GAA | |
| SCHEMBL19999908 | 0.79 | SSTR4 (0.39) | NPC1RAB9ASSTR4L3MBTL1GAA | |
| SCHEMBL3082319 | 0.77 | ALDH1A1 (0.48) | NPC1RAB9ASSTR4L3MBTL1GAA | |
| SCHEMBL3287339 | 0.77 | SSTR4 (0.46) | NPC1RAB9ASSTR4HPGDCYP1A2 | |
| SCHEMBL22470618 | 0.77 | SSTR4 (0.46) | SSTR4HTR2AKDM4EALOX5APFEN1 | |
| SCHEMBL4034458 | 0.77 | MAOB (0.51) | NPC1RAB9AL3MBTL1CYP3A4 | |
| SCHEMBL8776855 | 0.77 | MKNK1 (0.43) | SSTR4HPGDCYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231663-A2 | FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE AS C-MET INHIBITORS | Amgen, Inc (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009091374-A2 | FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2009-07-23 | — | — | WO | disclosed |
| US-4374140-A | 2-Substituted propoxy-3-cyano-5-hydroxypyridines and use as antihypertensives | MERCK & CO., INC. (US) | 1983-02-15 | — | — | US | disclosed |
| US-4329351-A | 2-Substituted propoxy-3-cyano-5-RO-pyridines and intermediates | MERCK & CO., INC. (US) | 1982-05-11 | — | — | US | disclosed |