Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.57 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.57 |
| ▸ | CYSLTR2 | Q9NS75 | 13/20 | 0.57 |
| ▸ | CYSLTR1 | Q9Y271 | 13/20 | 0.57 |
| ▸ | PPARG | P37231 | 2/20 | 0.50 |
| ▸ | PPARD | Q03181 | 2/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL8977854 | 0.97 | LTB4R (0.55) | LTB4RLTB4R2CYSLTR2CYSLTR1PPARG | |
| SCHEMBL9821733 | 0.90 | CYSLTR2 (0.60) | LTB4RLTB4R2CYSLTR2CYSLTR1PPARG | |
| SCHEMBL9042851 | 0.87 | LTB4R (0.57) | LTB4RLTB4R2CYSLTR2CYSLTR1PPARG | |
| SCHEMBL8825139 | 0.84 | PPARG (0.67) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL11042483 | 0.81 | GRM2 (0.69) | CYSLTR2CYSLTR1PPARGPPARDPPARA | |
| SCHEMBL9350005 | 0.79 | GRM2 (0.61) | LTB4RLTB4R2CYSLTR2CYSLTR1PPARG | |
| SCHEMBL8777242 | 0.79 | CYSLTR2 (0.69) | LTB4RLTB4R2CYSLTR2CYSLTR1PPARG | |
| SCHEMBL10556904 | 0.79 | CYSLTR2 (0.58) | LTB4RLTB4R2CYSLTR2CYSLTR1PPARG | |
| SCHEMBL10978263 | 0.78 | LTB4R (0.47) | LTB4RLTB4R2CYSLTR2CYSLTR1PPARG | |
| SCHEMBL9821860 | 0.78 | CYSLTR2 (0.61) | LTB4RLTB4R2CYSLTR2CYSLTR1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656896-B1 | NEW LEUKOTRIENE-B4 ANTAGONISTS, PROCESS FOR PREPARING THE SAME AND THEIR USE AS MEDICAMENTS | SCHERING AG (DE) | 1997-12-17 | — | — | EP | disclosed |
| US-5559134-A | Leukotriene-B4 antagonists, process for their production and their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-09-24 | — | — | US | disclosed |