Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 15/20 | 0.60 |
| ▸ | CYSLTR1 | Q9Y271 | 15/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | PPARD | Q03181 | 2/20 | 0.49 |
| ▸ | PPARA | Q07869 | 2/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777250 | 0.90 | LTB4R (0.57) | CYSLTR2CYSLTR1LMNAPPARGPPARD | |
| SCHEMBL9821860 | 0.88 | CYSLTR2 (0.61) | CYSLTR2CYSLTR1LMNAPPARGPPARD | |
| Ethylene SCHEMBL8977854 | 0.88 | LTB4R (0.55) | CYSLTR2CYSLTR1LMNAPPARGPPARD | |
| SCHEMBL8825139 | 0.84 | PPARG (0.67) | CYSLTR2CYSLTR1LMNAPPARGPPARD | |
| SCHEMBL10689994 | 0.81 | CYSLTR2 (0.62) | CYSLTR2CYSLTR1LMNAPPARGPPARD | |
| SCHEMBL11042483 | 0.81 | GRM2 (0.69) | CYSLTR2CYSLTR1LMNAPPARGPPARD | |
| SCHEMBL10688185 | 0.80 | CYSLTR2 (0.63) | CYSLTR2CYSLTR1LMNAPPARGPPARD | |
| SCHEMBL11050054 | 0.77 | PPARG (0.65) | CYSLTR2CYSLTR1LMNAPPARGPPARD | |
| SCHEMBL10775711 | 0.77 | CYSLTR2 (0.57) | CYSLTR2CYSLTR1LMNAPPARGPPARD | |
| SCHEMBL9042851 | 0.77 | LTB4R (0.57) | CYSLTR2CYSLTR1LMNAPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292977-B1 | ALKOXY-SUBSTITUTED DIHYDROBENZOPYRAN-2-CARBOXYLATE DERIVATIVES | G.D. Searle & Co. (US) | 1991-09-04 | — | — | EP | disclosed |
| US-4889871-A | ANTIINFLAMMATORY AGENTS; SELECTIVE LEUKOTRIENE ANTAGONISTS | G. D. SEARLE & CO. (US) | 1989-12-26 | — | — | US | disclosed |