SCHEMBL8777783

SCHEMBL8777783

Nc1cccc2c1C(=O)c1c(NC(=O)c3ccccc3)cccc1C2=O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.67
KMT2A Q03164 2/20 0.67
MMP14 P50281 1/20 0.67
CASP3 P42574 2/20 0.61
HDAC1 Q13547 3/20 0.60
HDAC2 Q92769 3/20 0.60
HDAC3 O15379 2/20 0.60
MAPK1 P28482 1/20 0.60
ADORA2A P29274 1/20 0.53
NCOR2 Q9Y618 1/20 0.51
MAOA P21397 1/20 0.51
CYP1A2 P05177 3/20 0.50
TSHR P16473 1/20 0.50
NPC1 O15118 2/20 0.48
RAB9A P51151 2/20 0.48
CCNE2 O96020 1/20 0.47
CCNE1 P24864 1/20 0.47
CDK2 P24941 1/20 0.47
POLB P06746 1/20 0.47
CCR6 P51684 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30611003 0.96 MEN1 (0.72) MEN1KMT2AMMP14CASP3HDAC1
SCHEMBL1982461 0.96 MEN1 (0.72) MEN1KMT2AMMP14CASP3HDAC1
SCHEMBL11841448 0.92 MEN1 (0.80) MEN1KMT2AMMP14CASP3HDAC1
SCHEMBL10705711 0.91 CASP3 (0.71) MEN1KMT2AMMP14CASP3HDAC1
SCHEMBL9861664 0.90 MEN1 (0.64) MEN1KMT2AMMP14CASP3HDAC1
SCHEMBL6142357 0.89 MEN1 (0.85) MEN1KMT2AMMP14CASP3HDAC1
SCHEMBL10728256 0.88 MEN1 (0.52) MEN1KMT2AMMP14CASP3HDAC1
SCHEMBL4622432 0.87 CASP3 (0.69) MEN1KMT2AMMP14CASP3HDAC1
SCHEMBL2877019 0.87 CASP3 (0.73) MEN1KMT2AMMP14CASP3HDAC1
SCHEMBL30111337 0.87 CASP3 (0.73) MEN1KMT2AMMP14CASP3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0099071-B1 PROCESS FOR THE PREPARATION OF MONOBENZOYLATED 1,4-DIAMINOANTHRAQUINONES BAYER AG (DE) 1988-06-29 EP claimed
US-4288362-A Monoazo pigments containing a quinazo linonylacetoacetanilide coupling component BAYER AKTIENGESELLSCHAFT (DE) 1981-09-08 US claimed
EP-0585873-B1 Method of preparing disazo pigments CLARIANT GMBH (DE) 1997-12-29 EP disclosed
US-5559216-A AZO COUPLING HOECHST AG (DE) 1996-09-24 US disclosed
US-5493011-A PIGMENTING HIGH MOLECULAR WEIGHT NATURAL OR SYNTHETIC ORGANIC MATERIALS HOECHST AG (DE) 1996-02-20 US disclosed
EP-0518909-B1 WATER-INSOLUBLE AZO DYES, THEIR MANUFACTURE AND USE HOECHST AG (DE) 1994-05-25 EP disclosed
EP-0585873-A1 Method of preparing disazo pigments HOECHST AKTIENGESELLSCHAFT (DE) 1994-03-09 EP disclosed
EP-0518909-A1 WATER-INSOLUBLE AZO DYES, THEIR MANUFACTURE AND USE. HOECHST AG (DE) 1992-12-23 EP disclosed
EP-0316649-B1 WATER INSOLUBLE AZO COLOURING AGENTS, THEIR PREPARATION AND USE HOECHST AKTIENGESELLSCHAFT (DE) 1992-07-22 EP disclosed
WO-1991013941-A1 WATER-INSOLUBLE AZO DYES, THEIR MANUFACTURE AND USE HOECHST AKTIENGESELLSCHAFT (DE) 1991-09-19 WO disclosed
US-5026831-A Water-insoluble disazo colorants having hetero-bicyclic methylene-active compounds as coupling component HOECHST AKTIENGESELLSCHAFT (DE) 1991-06-25 US disclosed
EP-0022209-A2 Fluor-triazine dyestuffs and their use in dyeing cellulosic fibrous materials BAYER AG (DE) 1981-01-14 EP disclosed
EP-0018538-A2 Anthraquinone derivatives, process for their preparation, process for the pigmentation of organic macromolecular materials and pigmented organic macromolecular material BAYER AG (DE) 1980-11-12 EP disclosed
US-4225489-A Heterocyclic azo dyes and pigments containing 4-quinazolinone moieties BAYER AKTIENGESELLSCHAFT (DE) 1980-09-30 US disclosed
EP-0008627-A2 Quinazoline derivatives, azo dyes derived from the quinazolines and their use as pigments BAYER AG (DE) 1980-03-19 EP disclosed
US-4082778-A ANTHRAQUINONE DYES, ORGANIC PIGMENTS CIBA-GEIGY CORPORATION (US) 1978-04-04 US disclosed
US-4076736-A Preparation of aminoanthraquinones from nitroanthraquinones BAYER AKTIENGESELLSCHAFT (DT) 1978-02-28 US disclosed
US-3963762-A Process for producing 1,5-dinitroanthraquinone and 1,8-dinitroanthraquinone BAYER AKTIENGESELLSCHAFT (DT) 1976-06-15 US disclosed
US-3956324-A THERMOPLASTIC POLYMER CIBA-GEIGY CORPORATION (US) 1976-05-11 US disclosed
US-3939113-A ANTHRAQUINONE DYES CIBA-GEIGY CORPORATION (US) 1976-02-17 US disclosed