Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.64 |
| ▸ | MAOA | P21397 | 3/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | CCR3 | P51677 | 6/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8805057 | 0.85 | MAOB (0.69) | MAOBMAOASIGMAR1KDM4EHSD17B10 | |
| SCHEMBL8804647 | 0.82 | MAOB (0.64) | MAOBMAOASIGMAR1KDM4EHSD17B10 | |
| SCHEMBL8805081 | 0.82 | MAOB (0.64) | MAOBMAOASIGMAR1KDM4EHSD17B10 | |
| SCHEMBL8804528 | 0.82 | KDM4E (0.64) | MAOBMAOASIGMAR1KDM4EHSD17B10 | |
| SCHEMBL8804925 | 0.82 | MAOB (0.71) | MAOBMAOASIGMAR1ACHECCR3 | |
| SCHEMBL8803570 | 0.81 | MAOB (0.60) | MAOBMAOASIGMAR1KDM4EHSD17B10 | |
| SCHEMBL8804219 | 0.81 | MAOB (0.65) | MAOBMAOASIGMAR1KDM4EHSD17B10 | |
| SCHEMBL8803034 | 0.80 | MAOB (0.61) | MAOBMAOASIGMAR1KDM4EHSD17B10 | |
| SCHEMBL8803135 | 0.80 | SIGMAR1 (0.67) | MAOBMAOASIGMAR1KDM4EHSD17B10 | |
| SCHEMBL8803545 | 0.80 | MAOB (0.62) | MAOBMAOASIGMAR1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |