Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8778117 | 1.00 | F10 (0.47) | F10PLK1PLK3MEN1KMT2A | |
| SCHEMBL8777969 | 0.87 | EPHX2 (0.52) | MEN1KMT2APTGS1PTGS2EPHX2 | |
| SCHEMBL8777938 | 0.86 | EPHX2 (0.49) | MEN1KMT2APTGS1PTGS2EPHX2 | |
| SCHEMBL8778024 | 0.84 | EPHX2 (0.46) | MEN1KMT2APTGS1PTGS2EPHX2 | |
| SCHEMBL8777912 | 0.83 | F10 (0.46) | F10PLK1PLK3MEN1KMT2A | |
| SCHEMBL8777917 | 0.82 | NAAA (0.45) | MEN1KMT2APTGS1PTGS2EPHX2 | |
| SCHEMBL8777926 | 0.78 | KMT2A (0.63) | F10MEN1KMT2ALPAR1PKM | |
| SCHEMBL8777810 | 0.77 | EPHX2 (0.48) | PTGS1PTGS2EPHX2EPHX1 | |
| SCHEMBL8777924 | 0.77 | P2RY1 (0.50) | MEN1KMT2APTGS1PTGS2EPHX2 | |
| SCHEMBL8777858 | 0.77 | F10 (0.49) | F10MEN1KMT2ALPAR1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |