Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.41 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777969 | 0.89 | EPHX2 (0.52) | EPHX2PTGS1PTGS2NR5A2NR5A1 | |
| SCHEMBL8777906 | 0.86 | F10 (0.47) | EPHX2PTGS1PTGS2RAB9ANR5A2 | |
| SCHEMBL8778117 | 0.86 | F10 (0.47) | EPHX2PTGS1PTGS2RAB9ANR5A2 | |
| SCHEMBL8778024 | 0.85 | EPHX2 (0.46) | EPHX2PTGS1PTGS2NR5A2NR5A1 | |
| SCHEMBL8777917 | 0.83 | NAAA (0.45) | EPHX2PTGS1PTGS2NR5A2NR5A1 | |
| SCHEMBL8777844 | 0.82 | SOAT1 (0.44) | ALDH1A1MAPTHDAC3HDAC1 | |
| SCHEMBL8777924 | 0.78 | P2RY1 (0.50) | EPHX2PTGS1PTGS2NR5A2NR5A1 | |
| SCHEMBL11781401 | 0.78 | PTGS1 (0.59) | PTGS1PTGS2NR5A2NR5A1ALDH1A1 | |
| SCHEMBL6543680 | 0.78 | PTGS1 (0.59) | PTGS1PTGS2NR5A2NR5A1ALDH1A1 | |
| SCHEMBL8777810 | 0.77 | EPHX2 (0.48) | EPHX2PTGS1PTGS2P2RY1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |