Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777913 | 0.98 | CYP19A1 (0.44) | TAAR1CYP19A1SLC18A2EPHX1 | |
| SCHEMBL8777965 | 0.98 | CYP19A1 (0.44) | TAAR1CYP19A1SLC18A2EPHX1 | |
| SCHEMBL8946022 | 0.95 | TAAR1 (0.49) | TAAR1CYP19A1SLC18A2ADRA2AADRA2B | |
| SCHEMBL7286965 | 0.90 | TAAR1 (0.50) | TAAR1CYP19A1SLC18A2 | |
| SCHEMBL1968440 | 0.88 | SLC18A2 (0.49) | TAAR1SLC18A2 | |
| SCHEMBL3154456 | 0.83 | SLC18A2 (0.50) | TAAR1SLC18A2 | |
| SCHEMBL2088026 | 0.82 | SPHK2 (0.36) | — | |
| SCHEMBL6003645 | 0.78 | CYSLTR2 (0.35) | SLC18A2 | |
| SCHEMBL42737 | 0.78 | NOS3 (0.53) | TAAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL2095798 | 0.77 | CNR1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |