Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374902 | 0.82 | SERPINE1 (0.54) | ALDH1A1SMN1; SMN2SERPINE1ALOX5TDP1 | |
| SCHEMBL28005923 | 0.80 | MAPT (0.59) | TTRMAPTCYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL8777982 | 0.79 | TSHR (0.58) | SMN1; SMN2SERPINE1NR1H4ALOX5TDP1 | |
| SCHEMBL11739738 | 0.78 | SERPINE1 (0.47) | MAPTCYP1A2CYP2C9ALDH1A1KMT2A | |
| SCHEMBL17165000 | 0.78 | MAPT (0.68) | TTRMAPTCYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL29405185 | 0.77 | MEN1 (0.51) | TTRMAPTCYP2C9ALDH1A1HTT | |
| SCHEMBL30727558 | 0.77 | MAPT (0.71) | TTRMAPTCYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL527543 | 0.77 | MAPT (0.71) | TTRMAPTCYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL9638781 | 0.77 | NR1H4 (0.53) | MAPTALDH1A1HTTKMT2AL3MBTL1 | |
| SCHEMBL11786628 | 0.76 | SELL (0.52) | HTTKMT2AL3MBTL1MEN1SERPINE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |