Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.50 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | F2R | P25116 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | ACR | P10323 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374902 | 0.87 | SERPINE1 (0.54) | TSHRSMN1; SMN2SERPINE1TNFRSF1APTGS2 | |
| SCHEMBL13292710 | 0.82 | SMN1; SMN2 (0.61) | TSHRSMN1; SMN2SERPINE1PTGS1NR1H4 | |
| SCHEMBL9280957 | 0.81 | ALOX5 (0.55) | SMN1; SMN2SERPINE1TNFRSF1APTGS2ALOX5 | |
| SCHEMBL11786628 | 0.81 | SELL (0.52) | SERPINE1TNFRSF1APTGS2ALOX5PTGS1 | |
| SCHEMBL1796301 | 0.80 | PTGS1 (0.48) | SMN1; SMN2SERPINE1TNFRSF1APTGS2ALOX5 | |
| SCHEMBL29612711 | 0.80 | PTGS1 (0.48) | SMN1; SMN2SERPINE1TNFRSF1APTGS2ALOX5 | |
| SCHEMBL11739738 | 0.80 | SERPINE1 (0.47) | SERPINE1TNFRSF1APTGS2ALOX5PTGS1 | |
| SCHEMBL11729947 | 0.79 | NSD2 (0.63) | SERPINE1TNFRSF1APTGS2ALOX5PTGS1 | |
| SCHEMBL8777915 | 0.79 | TTR (0.55) | SMN1; SMN2SERPINE1TNFRSF1APTGS2ALOX5 | |
| SCHEMBL13292741 | 0.78 | NPSR1 (0.59) | TSHRSMN1; SMN2TDP1LMNAPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |