Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.57 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27265696 | 0.89 | EPHX2 (0.69) | EPHX2RAB9AEPHX1ALDH1A1HTT | |
| SCHEMBL4129794 | 0.89 | EPHX2 (0.69) | EPHX2RAB9AEPHX1ALDH1A1HTT | |
| SCHEMBL8777853 | 0.80 | EPHX2 (0.57) | EPHX2RAB9AEPHX1ALDH1A1HTT | |
| SCHEMBL2618087 | 0.80 | HDAC1 (0.64) | HDAC3HDAC1NCOR2 | |
| SCHEMBL8777984 | 0.78 | EPHX2 (0.55) | EPHX2EPHX1ALDH1A1HTT | |
| SCHEMBL4783711 | 0.78 | EPHX2 (0.55) | EPHX2RAB9AEPHX1ALDH1A1HTT | |
| SCHEMBL27757715 | 0.78 | HDAC1 (0.62) | HDAC3HDAC1NCOR2 | |
| SCHEMBL4127306 | 0.78 | EPHX2 (0.68) | EPHX2RAB9AEPHX1ALDH1A1HTT | |
| SCHEMBL4141730 | 0.77 | EPHX1 (0.72) | EPHX2HDAC1EPHX1ALDH1A1HTT | |
| SCHEMBL11432520 | 0.77 | PKM (0.62) | EPHX2RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |