Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 13/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8777922 | 0.78 | EPHX2 (0.66) | EPHX2EPHX1ALDH1A1HTT | |
| SCHEMBL8777974 | 0.76 | EPHX2 (0.80) | EPHX2EPHX1ALDH1A1HTT | |
| SCHEMBL4348760 | 0.76 | EPHX2 (0.53) | EPHX2EPHX1ALDH1A1HTTMAPT | |
| SCHEMBL4341672 | 0.75 | EPHX1 (0.54) | EPHX2EPHX1ALDH1A1HTTMAPT | |
| SCHEMBL3993867 | 0.75 | ALDH1A1 (0.62) | EPHX2EPHX1ALDH1A1HTTMAPT | |
| SCHEMBL8602439 | 0.74 | EPHX2 (0.69) | EPHX2EPHX1ALDH1A1HTT | |
| SCHEMBL8602435 | 0.74 | EPHX2 (0.69) | EPHX2EPHX1ALDH1A1HTT | |
| SCHEMBL6442708 | 0.74 | EPHX1 (0.73) | EPHX2EPHX1ALDH1A1HTT | |
| SCHEMBL8598207 | 0.74 | EPHX1 (0.64) | EPHX2EPHX1ALDH1A1HTTMAPT | |
| SCHEMBL8597042 | 0.74 | EPHX1 (0.64) | EPHX2EPHX1ALDH1A1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |