Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 3/20 | 0.71 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 8/20 | 0.67 |
| ▸ | NPC1 | O15118 | 8/20 | 0.67 |
| ▸ | RAB9A | P51151 | 7/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7245174 | 0.85 | NPC1 (0.76) | ABCB1ABCC1MAPTNPC1RAB9A | |
| SCHEMBL29375530 | 0.81 | NPC1 (0.73) | ABCB1ABCC1MAPTNPC1RAB9A | |
| SCHEMBL8778033 | 0.81 | HDAC1 (0.50) | ABCB1ABCC1MAPTNPC1RAB9A | |
| SCHEMBL7917543 | 0.80 | ABCB1 (0.79) | ABCB1ABCC1MAPTNPC1RAB9A | |
| SCHEMBL6705974 | 0.79 | NPC1 (0.70) | ABCB1ABCC1MAPTNPC1RAB9A | |
| SCHEMBL6707064 | 0.79 | MAPT (0.77) | ABCB1ABCC1MAPTNPC1RAB9A | |
| SCHEMBL20356916 | 0.78 | ABCB1 (0.79) | ABCB1ABCC1MAPTNPC1RAB9A | |
| SCHEMBL6705958 | 0.76 | MAPT (0.68) | ABCB1ABCC1MAPTNPC1RAB9A | |
| SCHEMBL978808 | 0.76 | RAB9A (0.73) | MAPTNPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL978809 | 0.76 | RAB9A (0.73) | MAPTNPC1RAB9ASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665216-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5576335-A | TREATMENT OF HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-11-19 | — | — | US | disclosed |
| EP-0665216-A1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |