SCHEMBL8778142

SCHEMBL8778142

COc1cc([N+](=O)[O-])cc2c1OC1(C=C2)N(Cc2c(F)cccc2F)c2ccccc2C1(C)C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.42
MEN1 O00255 5/20 0.42
KMT2A Q03164 5/20 0.42
GAA P10253 4/20 0.42
SMN1; SMN2 Q16637 4/20 0.42
LMNA P02545 3/20 0.42
RECQL P46063 2/20 0.42
TDP1 Q9NUW8 2/20 0.42
PLIN1 O60240 1/20 0.42
THRB P10828 1/20 0.42
PKM P14618 1/20 0.42
TSHR P16473 1/20 0.42
PLIN5 Q00G26 1/20 0.42
ABHD5 Q8WTS1 1/20 0.42
NPSR1 Q6W5P4 3/20 0.35
ALPG P10696 1/20 0.35
TP53 P04637 1/20 0.35
ALOX15 P16050 1/20 0.35
HSD17B10 Q99714 1/20 0.35
ALDH1A1 P00352 4/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12265911 0.90 MAPT (0.44) MAPTMEN1KMT2AGAASMN1; SMN2
SCHEMBL14141068 0.90 MAPT (0.44) MAPTMEN1KMT2AGAASMN1; SMN2
SCHEMBL13491013 0.89 MAPT (0.41) MAPTMEN1KMT2AGAASMN1; SMN2
SCHEMBL13491012 0.89 MAPT (0.41) MAPTMEN1KMT2AGAASMN1; SMN2
SCHEMBL8775699 0.89 MAPT (0.42) MAPTMEN1KMT2AGAASMN1; SMN2
SCHEMBL12265918 0.89 MEN1 (0.44) MAPTMEN1KMT2AGAASMN1; SMN2
SCHEMBL8778055 0.89 MAPT (0.40) MAPTMEN1KMT2AGAASMN1; SMN2
SCHEMBL12787007 0.88 MAPT (0.42) MAPTMEN1KMT2AGAASMN1; SMN2
SCHEMBL8776080 0.88 MAPT (0.43) MAPTMEN1KMT2AGAASMN1; SMN2
SCHEMBL8680539 0.88 MAPT (0.46) MAPTMEN1KMT2AGAASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2102307-B1 PHOTOSTABILIZED TIME TEMPERATURE INDICATOR FRESHPOINT HOLDINGS SA (CH) 2012-05-23 EP disclosed
US-20100034961-A1 PHOTOSTABILIZED TIME TEMPERATURE INDICATOR FRESHPOINT HOLDINGS SA (CH) 2010-02-11 US disclosed
WO-2008083925-A1 PHOTOSTABILIZED TIME TEMPERATURE INDICATOR FRESHPOINT HOLDINGS SA (CH) 2008-07-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100034961-A1 PHOTOSTABILIZED TIME TEMPERATURE INDICATOR TTI1, NQO2, CCNI MAPT 3732/4885MEN1 828/4885KMT2A 4254/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.