Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 18/20 | 0.83 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.83 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.83 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.83 |
| ▸ | STK3 | Q13188 | 2/20 | 0.83 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.83 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.83 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.83 |
| ▸ | PLK4 | O00444 | 1/20 | 0.83 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.83 |
| ▸ | PRKCG | P05129 | 1/20 | 0.83 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.83 |
| ▸ | CDK2 | P24941 | 1/20 | 0.83 |
| ▸ | AKT1 | P31749 | 1/20 | 0.83 |
| ▸ | AKT2 | P31751 | 1/20 | 0.83 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.83 |
| ▸ | PRKCI | P41743 | 1/20 | 0.83 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.83 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.83 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL876811 | 0.99 | ROCK2 (0.82) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| SCHEMBL876705 | 0.91 | ROCK2 (1.00) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| Hydrochloric Acid SCHEMBL877736 | 0.90 | ROCK2 (0.99) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| SCHEMBL877500 | 0.90 | ROCK2 (0.99) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| SCHEMBL877070 | 0.90 | ROCK2 (0.76) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| Hydrochloric Acid SCHEMBL877236 | 0.90 | ROCK2 (0.97) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| SCHEMBL877058 | 0.90 | ROCK2 (0.92) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| Hydrochloric Acid SCHEMBL876602 | 0.90 | ROCK2 (0.75) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| SCHEMBL10218651 | 0.89 | ROCK2 (0.66) | ROCK2ROCK1PRKD3CSNK2A1STK3 | |
| Hydrochloric Acid SCHEMBL878344 | 0.89 | ROCK2 (0.91) | ROCK2ROCK1PRKD3CSNK2A1STK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120202793-A1 | RHO KINASE INHIBITORS | KADMON CORPORATION, LLC | 2012-08-09 | — | — | US | claimed |
| EP-2406236-A1 | RHO KINASE INHIBITORS | Surface Logix, Inc. (US) | 2012-01-18 | — | — | EP | claimed |
| WO-2010104851-A1 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2010-09-16 | — | — | WO | claimed |
| WO-2008054599-A2 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2008-05-08 | — | — | WO | claimed |
| US-20210017166-A1 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | SURFACE LOGIX LLC (US) | 2021-01-21 | — | — | US | disclosed |
| US-20210017166-A1 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | SURFACE LOGIX LLC (US) | 2021-01-21 | — | — | US | disclosed |
| US-10570123-B2 | Pharmacokinetically improved compounds | SURFACE LOGIX, LLC (US) | 2020-02-25 | — | — | US | disclosed |
| US-10570123-B2 | Pharmacokinetically improved compounds | SURFACE LOGIX, LLC (US) | 2020-02-25 | — | — | US | disclosed |
| US-20190177311-A1 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | SURFACE LOGIX, INC. | 2019-06-13 | — | — | US | disclosed |
| US-20190177311-A1 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | SURFACE LOGIX, INC. | 2019-06-13 | — | — | US | disclosed |
| US-20180072710-A1 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | SURFACE LOGIX INC (US) | 2018-03-15 | — | — | US | disclosed |
| US-20180072710-A1 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | SURFACE LOGIX INC (US) | 2018-03-15 | — | — | US | disclosed |
| WO-2010104851-A1 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2010-09-16 | — | — | WO | disclosed |
| US-20100144707-A1 | Pharmacokinetically improved compounds | SURFACE LOGIX, LLC | 2010-06-10 | — | — | US | disclosed |
| US-20100144707-A1 | Pharmacokinetically improved compounds | SURFACE LOGIX, LLC | 2010-06-10 | — | — | US | disclosed |
| US-20100144707-A1 | Pharmacokinetically improved compounds | SURFACE LOGIX, LLC | 2010-06-10 | — | — | US | disclosed |
| WO-2008054599-A2 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| WO-2008054599-A2 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2008-05-08 | — | — | WO | disclosed |
| EP-1865958-A2 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | Surface Logix, Inc. (US) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006105081-A2 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | SURFACE LOGIX, INC. (US) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072710-A1 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | ROCK2, ROCK1, RHOT2 | ROCK2 1/4885ROCK1 2/4885PRKD3 322/4885 |
| US-20190177311-A1 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | ROCK2, ROCK1, RHOT2 | ROCK2 1/4885ROCK1 2/4885PRKD3 322/4885 |
| US-20210017166-A1 | PHARMACOKINETICALLY IMPROVED COMPOUNDS | ROCK2, ROCK1, RHOT2 | ROCK2 1/4885ROCK1 2/4885PRKD3 322/4885 |
| US-20100144707-A1 | Pharmacokinetically improved compounds | ROCK2, ROCK1, RHOT2 | ROCK2 1/4885ROCK1 2/4885PRKD3 322/4885 |
| US-10570123-B2 | Pharmacokinetically improved compounds | ROCK2, ROCK1, RHOT2 | ROCK2 1/4885ROCK1 2/4885PRKD3 322/4885 |
| US-20120202793-A1 | RHO KINASE INHIBITORS | ROCK2, ROCK1, RHOA | ROCK2 1/4885ROCK1 2/4885PRKD3 150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.