Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | AGXT | P21549 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.45 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7633032 | 0.90 | TDP1 (0.66) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL8778562 | 0.86 | KDM4E (0.56) | TDP1KDM4ERAB9AMAPTSMN1; SMN2 | |
| SCHEMBL95651 | 0.84 | TDP1 (0.63) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL8778566 | 0.83 | TDP1 (0.61) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL1534924 | 0.83 | TDP1 (0.61) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL16893744 | 0.83 | TDP1 (0.61) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL16893725 | 0.83 | TDP1 (0.61) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL1534971 | 0.83 | TDP1 (0.61) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL71967 | 0.81 | TDP1 (0.68) | TDP1KDM4EMAPK1NPC1RAB9A | |
| SCHEMBL16890178 | 0.80 | CYP1A2 (0.56) | TDP1KDM4EMAPK1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574355-B1 | Phosphinyloxy propanaminium inner salt derivatives | CIBA GEIGY AG (CH) | 1997-08-13 | — | — | EP | claimed |
| EP-0574355-A1 | Phosphinyloxy propanaminium inner salt derivatives | SANDOZ LTD. (CH) | 1993-12-15 | — | — | EP | claimed |