(Phenylsulfonyl)Benzene

(Phenylsulfonyl)Benzene

SCHEMBL8778772

CCO.O=S(=O)(c1ccccc1)c1ccccc1

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of (Phenylsulfonyl)Benzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 known ✓ P03956 1/20 0.44
MMP8 known ✓ P22894 1/20 0.44
MMP13 known ✓ P45452 1/20 0.44
HTR6 P50406 7/20 0.70
PSIP1 O75475 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.56
SMN1; SMN2 Q16637 3/20 0.50
HSD11B1 P28845 2/20 0.50
TSHR P16473 1/20 0.50
ALDH1A1 P00352 2/20 0.47
MAPT P10636 2/20 0.47
POLB P06746 1/20 0.47
MAOA P21397 1/20 0.46
LOX P28300 1/20 0.46
LOXL2 Q9Y4K0 1/20 0.46
GAA P10253 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
MMP2 P08253 1/20 0.44
MMP9 P14780 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
(Phenylsulfonyl)Benzene SCHEMBL8778747 0.91 HTR6 (0.64) HTR6PSIP1L3MBTL1SMN1; SMN2HSD11B1
(Phenylsulfonyl)Benzene SCHEMBL28237512 0.87 HTR6 (0.93) HTR6PSIP1L3MBTL1SMN1; SMN2HSD11B1
(Phenylsulfonyl)Benzene SCHEMBL9642019 0.84 HTR6 (0.88) HTR6PSIP1L3MBTL1SMN1; SMN2HSD11B1
(Phenylsulfonyl)Benzene SCHEMBL29473549 0.84 HTR6 (1.00) HTR6PSIP1SMN1; SMN2TSHRALDH1A1
(Phenylsulfonyl)Benzene SCHEMBL30255 0.84 HTR6 (1.00) HTR6PSIP1SMN1; SMN2TSHRALDH1A1
(Phenylsulfonyl)Benzene SCHEMBL29775288 0.84 HTR6 (1.00) HTR6PSIP1SMN1; SMN2TSHRALDH1A1
(Phenylsulfonyl)Benzene SCHEMBL13735236 0.84 HTR6 (1.00) HTR6PSIP1SMN1; SMN2TSHRALDH1A1
(Phenylsulfonyl)Benzene SCHEMBL29450723 0.84 HTR6 (1.00) HTR6PSIP1SMN1; SMN2TSHRALDH1A1
(Phenylsulfonyl)Benzene SCHEMBL28119187 0.84 HTR6 (1.00) HTR6PSIP1SMN1; SMN2TSHRALDH1A1
Alcohol SCHEMBL281881 0.83 TSHR (0.76) HTR6PSIP1SMN1; SMN2HSD11B1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0602914-B1 Ink compositions for ink jet printing XEROX CORP (US) 1997-11-12 EP claimed
US-5300143-A Water soluble dye, sulfone, and amide or cyclic amine XEROX CORPORATION (US) 1994-04-05 US claimed
CN-110312752-A Poly (ether ketone) polymers, corresponding methods of synthesis and polymer compositions, and articles made therefrom 索尔维特殊聚合物美国有限责任公司 2019-10-08 CN disclosed
EP-0602914-B1 Ink compositions for ink jet printing XEROX CORP (US) 1997-11-12 EP disclosed
EP-0602914-A1 Ink compositions for ink jet printing XEROX CORPORATION (US) 1994-06-22 EP disclosed
US-5300143-A Water soluble dye, sulfone, and amide or cyclic amine XEROX CORPORATION (US) 1994-04-05 US disclosed